Function and Biology

Dengue 3 NS5 protein with compound 29

Source organism: Dengue virus 3
Biochemical function: methyltransferase activity
Biological process: viral RNA genome replication
Cellular component: not assigned

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.91: Flavivirin

Reaction catalysed:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Alternative Name(s):
  • NS2B-3 proteinase
  • Yellow fever virus (flavivirus) protease
  • Yellow fever virus protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

EC 2.1.1.57: Methyltransferase cap1

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
  • Cap1-MTase
  • MTR1
  • Messenger RNA (nucleoside-2'-)-methyltransferase
  • Messenger ribonucleate nucleoside 2'-methyltransferase
  • S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
  • mRNA (nucleoside-2'-O)-methyltransferase

EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • Guanine-7-methyltransferase
  • Messenger RNA guanine 7-methyltransferase
  • Messenger ribonucleate guanine 7-methyltransferase
  • S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

Sequence families

Pfam Protein families (Pfam)
PF20483
Domain description: Flavivirus RNA-directed RNA polymerase, thumb domain
Occurring in:
  1. RNA-directed RNA polymerase NS5
The deposited structure of PDB entry 5jjr contains 1 copy of Pfam domain PF20483 (Flavivirus RNA-directed RNA polymerase, thumb domain) in RNA-directed RNA polymerase NS5. Showing 1 copy in chain A.

PF00972
Domain description: Flavivirus RNA-directed RNA polymerase, fingers and palm domains
Occurring in:
  1. RNA-directed RNA polymerase NS5
The deposited structure of PDB entry 5jjr contains 1 copy of Pfam domain PF00972 (Flavivirus RNA-directed RNA polymerase, fingers and palm domains) in RNA-directed RNA polymerase NS5. Showing 1 copy in chain A.

PF01728
Domain description: FtsJ-like methyltransferase
Occurring in:
  1. RNA-directed RNA polymerase NS5
The deposited structure of PDB entry 5jjr contains 1 copy of Pfam domain PF01728 (FtsJ-like methyltransferase) in RNA-directed RNA polymerase NS5. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR026490
Domain description: mRNA cap 0/1 methyltransferase
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR046811
Domain description: RNA-directed RNA polymerase, thumb subdomain, flavivirus
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR007094
Domain description: RNA-directed RNA polymerase, catalytic domain
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR047530
Domain description: RNA-dependent RNA polymerase, flavivirus
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR000208
Domain description: RNA-directed RNA polymerase, fingers/palm subdomains, flavivirus
Occurring in:
  1. RNA-directed RNA polymerase NS5
IPR002877
Domain description: Ribosomal RNA methyltransferase, FtsJ domain
Occurring in:
  1. RNA-directed RNA polymerase NS5