PDBe 5j8e

X-ray diffraction
1.7Å resolution

Crystal structure of human Hook3's conserved Hook domain

Released:
Source organism: Homo sapiens
Primary publication:
Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
OpenAccess logo J. Cell Biol. 214 309-18 (2016)
PMID: 27482052

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Hook homolog 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VS8 (Residues: 1-160; Coverage: 22%)
Gene name: HOOK3
Structure domains: Calponin-like domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Unit cell:
a: 33.92Å b: 75.88Å c: 111.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.184 0.214
Expression system: Escherichia coli