PDBe 5ire

Electron Microscopy
3.8Å resolution

The cryo-EM structure of Zika Virus

Released:
Source organism: Zika virus
Related structures: EMD-8116

Function and Biology Details

Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA]
ATP + H(2)O = ADP + phosphate
NTP + H(2)O = NDP + phosphate
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero 360-mer (preferred)
hetero hexamer
hetero 30-mer
hetero 36-mer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Envelope protein E Chains: A, C, E
Small envelope protein M Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 75 amino acids
Theoretical weight: 8.5 KDa
Source organism: Zika virus
UniProt:
  • Canonical: A0A024B7W1 (Residues: 216-290; Coverage: 2%)
Sequence domains: Flavivirus envelope glycoprotein M
Structure domains: Helicase, Ruva Protein; domain 3

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-8116