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Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide

X-ray diffraction
2.27Å resolution
PDB entry 5hpe coloured by chain, front view.
PDB entry 5hpe coloured by chain, side view.
PDB entry 5hpe coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hsp90 co-chaperone Cdc37, N-terminally processed, Serine/threonine-protein phosphatase 5
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Multimeric state: monomeric
Accessible surface area: 13769.67 Å2
Buried surface area: 563.7 Å2
Dissociation area: 79.1 Å2
Dissociation energy (ΔGdiss): -0.51 kcal/mol
Dissociation entropy (TΔSdiss): 1.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156701

Macromolecules

Hsp90 co-chaperone Cdc37, N-terminally processed; Serine/threonine-protein phosphatase 5
Chain: A
Length: 350 amino acids
Theoretical weight: 39.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53041 (Residues: 175-499; Coverage: 65%)
  • Canonical: Q16543 (Residues: 5-20; Coverage: 4%)
    • nullnull
Gene names: CDC37, CDC37A, PPP5, PPP5C
Pfam:
InterPro:
CATH: Purple Acid Phosphatase; chain A, domain 2
Hsp90 co-chaperone Cdc37, N-terminally processed in PDB entry 5hpe, assembly 1, front view.
Hsp90 co-chaperone Cdc37, N-terminally processed in PDB entry 5hpe, assembly 1, side view.
Hsp90 co-chaperone Cdc37, N-terminally processed in PDB entry 5hpe, assembly 1, top view.
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