Structure analysis

X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV).

X-ray diffraction
2.295Å resolution
Source organism: Homo sapiens
Assemblies composition:
homo dodecamer
homo trimer (preferred)
homo hexamer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: homo dodecamer
Accessible surface area: 12739.74 Å2
Buried surface area: 13770.97 Å2
Dissociation area: 6,623.94 Å2
Dissociation energy (ΔGdiss): 23.97 kcal/mol
Dissociation entropy (TΔSdiss): 97.07 kcal/mol
Symmetry number: 12
PDBe Complex ID: PDB-CPX-138392
Assembly 2
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Multimeric state: homo trimer
Accessible surface area: 4682.63 Å2
Buried surface area: 1527.55 Å2
Dissociation area: 763.78 Å2
Dissociation energy (ΔGdiss): 0.2 kcal/mol
Dissociation entropy (TΔSdiss): 16.21 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-138398
Assembly 3
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Multimeric state: homo hexamer
Accessible surface area: 8453.51 Å2
Buried surface area: 3966.85 Å2
Dissociation area: 1,983.42 Å2
Dissociation energy (ΔGdiss): 0.98 kcal/mol
Dissociation entropy (TΔSdiss): 41.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138402
Assembly 4 (preferred)
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Multimeric state: homo trimer
Accessible surface area: 4903.11 Å2
Buried surface area: 2141.41 Å2
Dissociation area: 937.59 Å2
Dissociation energy (ΔGdiss): 4.11 kcal/mol
Dissociation entropy (TΔSdiss): 16.75 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-138398
Assembly 5
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Multimeric state: homo hexamer
Accessible surface area: 8095.42 Å2
Buried surface area: 5986.66 Å2
Dissociation area: 851.87 Å2
Dissociation energy (ΔGdiss): 2.74 kcal/mol
Dissociation entropy (TΔSdiss): 9.51 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138402

Macromolecules

Chains: A, B, C, D, E, F
Length: 21 amino acids
Theoretical weight: 2.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 688-707; Coverage: 3%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
InterPro:

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