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Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: lipid metabolic process
Cellular component: nucleus

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-beta
  2. Oxysterols receptor LXR-beta
The deposited structure of PDB entry 5hjp contains 2 copies of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Retinoic acid receptor RXR-beta. Showing 1 copy in chain C.
The deposited structure of PDB entry 5hjp contains 2 copies of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Oxysterols receptor LXR-beta. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-beta
  2. Oxysterols receptor LXR-beta
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Retinoic acid receptor RXR-beta
  2. Oxysterols receptor LXR-beta
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Retinoic acid receptor RXR-beta
  2. Oxysterols receptor LXR-beta
IPR023257
Domain description: Liver X receptor
Occurring in:
  1. Oxysterols receptor LXR-beta
IPR000003
Domain description: Retinoid X receptor/HNF4
Occurring in:
  1. Retinoic acid receptor RXR-beta

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Retinoic acid receptor RXR-beta
  2. Oxysterols receptor LXR-beta
The deposited structure of PDB entry 5hjp contains 2 copies of CATH domain 1.10.565.10 (Retinoid X Receptor) in Retinoic acid receptor RXR-beta. Showing 1 copy in chain C.
The deposited structure of PDB entry 5hjp contains 2 copies of CATH domain 1.10.565.10 (Retinoid X Receptor) in Oxysterols receptor LXR-beta. Showing 1 copy in chain B.

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