EC 2.1.1.354: [Histone H3]-lysine(4) N-trimethyltransferase
Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(4) N(6)-methyltransferase
GO terms
Biochemical function:
- histone H3K4 trimethyltransferase activity
- histone H3K36 dimethyltransferase activity
- histone H4 methyltransferase activity
- metal ion binding
- histone methyltransferase activity
- methyltransferase activity
- protein binding
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- RNA polymerase II complex binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological process:
Cellular component:
Sequence families
Structure domains
CATH domains
2.170.270.10
Class:
Mainly Beta
Architecture:
Beta Complex
Topology:
Beta-clip-like
Homology:
SET domain
Occurring in:
1.25.40.10
Class:
Mainly Alpha
Architecture:
Alpha Horseshoe
Topology:
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology:
Tetratricopeptide repeat domain
Occurring in:
1.25.40.970
Class:
Mainly Alpha
Architecture:
Alpha Horseshoe
Topology:
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology:
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Occurring in:
1.10.220.160
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Annexin V; domain 1
Homology:
Annexin V; domain 1
Occurring in: