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X-Ray structure of H243I mutant of UDP-Galactose 4-epimerase from E.coli:evidence for existence of open and closed active site during catalysis.

X-ray diffraction
1.43Å resolution
PDB entry 5gy7 coloured by chain, front view.
PDB entry 5gy7 coloured by chain, side view.
PDB entry 5gy7 coloured by chain, top view.
Source organism: Escherichia coli K-12
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: UDP-glucose 4-epimerase
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Multimeric state: homo dimer
Accessible surface area: 23192.34 Å2
Buried surface area: 5959.49 Å2
Dissociation area: 881.67 Å2
Dissociation energy (ΔGdiss): 6.02 kcal/mol
Dissociation entropy (TΔSdiss): 13.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-140567

Macromolecules

UDP-glucose 4-epimerase
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.11 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P09147 (Residues: 1-338; Coverage: 100%)
Gene names: JW0742, b0759, galD, galE
Pfam: NAD dependent epimerase/dehydratase family
InterPro:
CATH:
UDP-glucose 4-epimerase in PDB entry 5gy7, assembly 1, front view.
UDP-glucose 4-epimerase in PDB entry 5gy7, assembly 1, side view.
UDP-glucose 4-epimerase in PDB entry 5gy7, assembly 1, top view.
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