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Structural Insights into BAF47 and BAF155 Complex Formation.

Yan L, Xie S, Du Y, Qian C
J Mol Biol 429 1650-1660 (2017)
Cited: 17 times
EuropePMC logo PMID: 28438634

Abstract

Mammalian BAF complexes are a subfamily of SWI/SNF ATP-dependent chromatin remodelers that dynamically modulate chromatin structure to regulate fundamental cellular processes including gene transcription, cell cycle control, and DNA damage response. So far, many distinct BAF complexes have been identified with polymorphic assemblies of up to 15 subunits from 29 genes. The evolutionarily conserved BRG1/BRM, BAF47, and BAF155/BAF170 form a stable complex that carries out essential chromatin remodeling activity and therefore have been regarded as the core components of BAF complex. Here, we first confirmed that SWIRM domain of BAF155 is responsible for its interaction with BAF47 and then narrowed down the SWIRM-binding region in BAF47 to the Repeat 1 (RPT1) domain. We further presented the high-resolution crystal structure of SWIRM/RPT1 complex. Extensive mutagenesis experiments together with isothermal titration calorimetry and NMR titrations were performed to corroborate the interactions observed in crystal structure. Overall, we demonstrated that BAF155 SWIRM is a modular domain involved in BAF47 interaction, which is functionally distinct from other characterized SWIRM domains that possess DNA binding activity.

Articles - 5gjk mentioned but not cited (4)

  1. Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Han Y, Reyes AA, Malik S, He Y. Nature 579 452-455 (2020)
  2. Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development. El Hadidy N, Uversky VN. Int J Mol Sci 20 E5260 (2019)
  3. INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication. Dixit U, Bhutoria S, Wu X, Qiu L, Spira M, Mathew S, Harris R, Adams LJ, Cahill S, Pathak R, Rajesh Kumar P, Nguyen M, Acharya SA, Brenowitz M, Almo SC, Zou X, Steven AC, Cowburn D, Girvin M, Kalpana GV. Nat Commun 12 2743 (2021)
  4. A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction. Han J, Kim I, Park JH, Yun JH, Joo K, Kim T, Park GY, Ryu KS, Ko YJ, Mizutani K, Park SY, Seong RH, Lee J, Suh JY, Lee W. Int J Mol Sci 21 E2452 (2020)


Reviews citing this publication (2)

  1. Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments. Ngo C, Postel-Vinay S. Biomedicines 10 650 (2022)
  2. The structural biology of canonical Wnt signalling. Agostino M, Pohl SÖ. Biochem Soc Trans 48 1765-1780 (2020)

Articles citing this publication (11)

  1. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Mashtalir N, D'Avino AR, Michel BC, Luo J, Pan J, Otto JE, Zullow HJ, McKenzie ZM, Kubiak RL, St Pierre R, Valencia AM, Poynter SJ, Cassel SH, Ranish JA, Kadoch C. Cell 175 1272-1288.e20 (2018)
  2. Structure of the RSC complex bound to the nucleosome. Ye Y, Wu H, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR, Gao N, Chen Z. Science 366 838-843 (2019)
  3. A chemoproteomic portrait of the oncometabolite fumarate. Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, Weerapana E, Linehan WM, Meier JL. Nat Chem Biol 15 391-400 (2019)
  4. Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. Patel AB, Moore CM, Greber BJ, Luo J, Zukin SA, Ranish J, Nogales E. Elife 8 e54449 (2019)
  5. The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex. Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G. FEBS J 285 4165-4180 (2018)
  6. SWI/SNF Infobase-An exclusive information portal for SWI/SNF remodeling complex subunits. Mani U, S AS, Goutham R N A, Mohan S S. PLoS One 12 e0184445 (2017)
  7. A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex. Chen G, Zhou H, Liu B, Wang Y, Zhao J, Giancotti FG, Long J. Cell Discov 6 66 (2020)
  8. Modulating the Expression Strength of the Baculovirus/Insect Cell Expression System: A Toolbox Applied to the Human Tumor Suppressor SMARCB1/SNF5. Golas MM, Jayaprakash S, Le LTM, Zhao Z, Heras Huertas V, Jensen IS, Yuan J, Sander B. Mol Biotechnol 60 820-832 (2018)
  9. Retrospective analysis of a clinical exome sequencing cohort reveals the mutational spectrum and identifies candidate disease-associated loci for BAFopathies. Chen CA, Lattier J, Zhu W, Rosenfeld J, Wang L, Scott TM, Du H, Patel V, Dang A, Magoulas P, Streff H, Sebastian J, Svihovec S, Curry K, Delgado MR, Hanchard NA, Lalani S, Marom R, Madan-Khetarpal S, Saenz M, Dai H, Meng L, Xia F, Bi W, Liu P, Posey JE, Scott DA, Lupski JR, Eng CM, Xiao R, Yuan B. Genet Med 24 364-373 (2022)
  10. SMARCC1 Enters the Nucleus via KPNA2 and Plays an Oncogenic Role in Bladder Cancer. Wei Z, Xu J, Li W, Ou L, Zhou Y, Wang Y, Shi B. Front Mol Biosci 9 902220 (2022)
  11. Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers. Auman HJ, Fernandes IH, Berríos-Otero CA, Colombo S, Yelon D. Dev Dyn (2023)


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