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Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA

Source organisms:
Biochemical function: metal ion binding
Biological process: defense response to virus
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF16595
Domain description: PAM-interacting domain of CRISPR-associated endonuclease Cas9
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
The deposited structure of PDB entry 5fw1 contains 1 copy of Pfam domain PF16595 (PAM-interacting domain of CRISPR-associated endonuclease Cas9) in CRISPR-associated endonuclease Cas9/Csn1. Showing 1 copy in chain B.

PF13395
Domain description: HNH endonuclease
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
The deposited structure of PDB entry 5fw1 contains 1 copy of Pfam domain PF13395 (HNH endonuclease) in CRISPR-associated endonuclease Cas9/Csn1. Showing 1 copy in chain B.

PF16592
Domain description: REC lobe of CRISPR-associated endonuclease Cas9
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
The deposited structure of PDB entry 5fw1 contains 1 copy of Pfam domain PF16592 (REC lobe of CRISPR-associated endonuclease Cas9) in CRISPR-associated endonuclease Cas9/Csn1. Showing 1 copy in chain B.

PF16593
Domain description: Bridge helix of CRISPR-associated endonuclease Cas9
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
The deposited structure of PDB entry 5fw1 contains 1 copy of Pfam domain PF16593 (Bridge helix of CRISPR-associated endonuclease Cas9) in CRISPR-associated endonuclease Cas9/Csn1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR028629
Domain description: CRISPR-associated endonuclease Cas9
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
IPR032237
Domain description: CRISPR-associated endonuclease Cas9, PAM-interacting domain
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
IPR003615
Domain description: HNH nuclease
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
IPR033114
Domain description: Cas9-type HNH domain
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
IPR032240
Domain description: CRISPR-associated endonuclease Cas9, REC lobe
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1
IPR032239
Domain description: CRISPR-associated endonuclease Cas9, bridge helix
Occurring in:
  1. CRISPR-associated endonuclease Cas9/Csn1

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