PDBe 5fit

X-ray diffraction
2.3Å resolution

FHIT-SUBSTRATE ANALOG

Released:

Function and Biology Details

Reaction catalysed:
P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bis(5'-adenosyl)-triphosphatase Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 16.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49789 (Residues: 1-147; Coverage: 100%)
Gene name: FHIT
Sequence domains: HIT domain
Structure domains: HIT family, subunit A

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6122
Unit cell:
a: 50.64Å b: 50.64Å c: 267.52Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.226 0.258
Expression system: Escherichia coli