› 5fg5

X-ray diffraction
1.5Å resolution

Crystal structure of the bromodomain of human BRPF1 in complex with PFI-4 chemical probe

Released:
DOI: 10.2210/pdb5fg5/pdb
PDB entry 5fg5 coloured by chain, front view.
PDB entry 5fg5 coloured by chain, side view.
PDB entry 5fg5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Owen DR, Gerstenberger BS, Savitsky P, Chaikuad A, Fedorov O, Nunez-Alonso G, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Muller S, Brennan PE, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157220 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand 5XF 2 x 5XF
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Unit cell:
a: 57.919Å b: 68.141Å c: 72.656Å
α: 90° β: 94.33° γ: 90°
R-values:
R R work R free
0.168 0.167 0.186
Expression system: Escherichia coli

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