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Structure of Lin54 tesmin domain bound to DNA

X-ray diffraction
2.42Å resolution
PDB entry 5fd3 coloured by chain, front view.
PDB entry 5fd3 coloured by chain, side view.
PDB entry 5fd3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein lin-54 homolog and DNA
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Multimeric state: hetero trimer
Accessible surface area: 11177.56 Å2
Buried surface area: 3246.05 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118669
Assembly 2
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Assembly Name: Protein lin-54 homolog and DNA
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Multimeric state: hetero trimer
Accessible surface area: 11140.06 Å2
Buried surface area: 3319.34 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118669

Macromolecules

Protein lin-54 homolog
Chains: A, B
Length: 135 amino acids
Theoretical weight: 15.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6MZP7 (Residues: 515-646; Coverage: 18%)
Gene names: CXCDC1, KIAA2037, LIN54
Pfam: Tesmin/TSO1-like CXC domain, cysteine-rich domain
InterPro:
Protein lin-54 homolog in PDB entry 5fd3, assembly 1, front view.
Protein lin-54 homolog in PDB entry 5fd3, assembly 1, side view.
Protein lin-54 homolog in PDB entry 5fd3, assembly 1, top view.
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DNA chains C, H
Name: DNA (5'-D(*GP*AP*GP*TP*TP*TP*GP*AP*AP*AP*CP*T)-3')
Representative chains: C, H
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.7 KDa
DNA (5'-D(*GP*AP*GP*TP*TP*TP*GP*AP*AP*AP*CP*T)-3') in PDB entry 5fd3, assembly 1, front view.
DNA (5'-D(*GP*AP*GP*TP*TP*TP*GP*AP*AP*AP*CP*T)-3') in PDB entry 5fd3, assembly 1, side view.
DNA (5'-D(*GP*AP*GP*TP*TP*TP*GP*AP*AP*AP*CP*T)-3') in PDB entry 5fd3, assembly 1, top view.
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DNA chains D, I
Name: DNA (5'-D(*CP*AP*GP*TP*TP*TP*CP*AP*AP*AP*CP*TP*C)-3')
Representative chains: D, I
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 13 nucleotides
Theoretical weight: 3.91 KDa
DNA (5'-D(*CP*AP*GP*TP*TP*TP*CP*AP*AP*AP*CP*TP*C)-3') in PDB entry 5fd3, assembly 1, front view.
DNA (5'-D(*CP*AP*GP*TP*TP*TP*CP*AP*AP*AP*CP*TP*C)-3') in PDB entry 5fd3, assembly 1, side view.
DNA (5'-D(*CP*AP*GP*TP*TP*TP*CP*AP*AP*AP*CP*TP*C)-3') in PDB entry 5fd3, assembly 1, top view.
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