PDBe 5f9e

X-ray diffraction
2Å resolution

Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C theta type Chains: A, B
Molecule details ›
Chains: A, B
Length: 353 amino acids
Theoretical weight: 41.96 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q04759 (Residues: 361-706; Coverage: 49%)
Gene names: PRKCQ, PRKCT
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 75.603Å b: 76.786Å c: 149.304Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.233
Expression system: unidentified baculovirus