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Crystal structure of human KDM4A in complex with compound 15

X-ray diffraction
2.08Å resolution
PDB entry 5f2s coloured by chain, front view.
PDB entry 5f2s coloured by chain, side view.
PDB entry 5f2s coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Lysine-specific demethylase 4A
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Multimeric state: monomeric
Accessible surface area: 14449.74 Å2
Buried surface area: 2175.42 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130863
Assembly 2
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Assembly Name: Lysine-specific demethylase 4A
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Multimeric state: monomeric
Accessible surface area: 15358.06 Å2
Buried surface area: 2501.14 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130863
Assembly 3
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Assembly Name: Lysine-specific demethylase 4A
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Multimeric state: monomeric
Accessible surface area: 14970.49 Å2
Buried surface area: 2294.46 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130863
Assembly 4 (preferred)
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Assembly Name: Lysine-specific demethylase 4A
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Multimeric state: monomeric
Accessible surface area: 15307.78 Å2
Buried surface area: 2691.61 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130863

Macromolecules

Lysine-specific demethylase 4A
Chains: A, B, C, D
Length: 360 amino acids
Theoretical weight: 41.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75164 (Residues: 1-359; Coverage: 34%)
Gene names: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
Pfam:
InterPro:
CATH: Cupin
Lysine-specific demethylase 4A in PDB entry 5f2s, assembly 4, front view.
Lysine-specific demethylase 4A in PDB entry 5f2s, assembly 4, side view.
Lysine-specific demethylase 4A in PDB entry 5f2s, assembly 4, top view.
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