› 5eyx

X-ray diffraction
2.25Å resolution

Monoclinic Form of Centrolobium tomentosum seed lectin (CTL) complexed with Man1-3Man-OMe.

Released:
DOI: 10.2210/pdb5eyx/pdb
PDB entry 5eyx coloured by chain, front view.
PDB entry 5eyx coloured by chain, side view.
PDB entry 5eyx coloured by chain, top view.
Source organism: Centrolobium tomentosum
Primary publication:
Structural analysis of Centrolobium tomentosum seed lectin with inflammatory activity.
Almeida AC, Osterne VJ, Santiago MQ, Pinto-Junior VR, Silva-Filho JC, Lossio CF, Nascimento FL, Almeida RP, Teixeira CS, Leal RB, Delatorre P, Rocha BA, Assreuy AM, Nascimento KS, Cavada BS
Arch Biochem Biophys 596 73-83 (2016)
PMID: 26946944

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Mannose/glucose-specific lectin Chains: A, B
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 27.08 KDa
Source organism: Centrolobium tomentosum
UniProt:
  • Canonical: C0HJX1 (Residues: 1-245; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: MMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand CA 2 x CA
Ligand MN 2 x MN
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: C2
Unit cell:
a: 145.84Å b: 41.55Å c: 94.64Å
α: 90° β: 102.4° γ: 90°
R-values:
R R work R free
0.188 0.186 0.237

Quick links

Citations

2 review citations

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives.
Barre et al. (2021)
1 more

1 mention without citation

Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.
Barre et al. (2019)