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Human GLUT1 in complex with inhibitor (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide

X-ray diffraction
2.99Å resolution
PDB entry 5eqh coloured by chain, front view.
PDB entry 5eqh coloured by chain, side view.
PDB entry 5eqh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Solute carrier family 2, facilitated glucose transporter member 1
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Multimeric state: monomeric
Accessible surface area: 18761.09 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145688

Macromolecules

Solute carrier family 2, facilitated glucose transporter member 1
Chain: A
Length: 492 amino acids
Theoretical weight: 54.13 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P11166 (Residues: 1-492; Coverage: 100%)
Gene names: GLUT1, SLC2A1
Pfam: Sugar (and other) transporter
InterPro:
CATH: MFS general substrate transporter like domains
Solute carrier family 2, facilitated glucose transporter member 1 in PDB entry 5eqh, assembly 1, front view.
Solute carrier family 2, facilitated glucose transporter member 1 in PDB entry 5eqh, assembly 1, side view.
Solute carrier family 2, facilitated glucose transporter member 1 in PDB entry 5eqh, assembly 1, top view.
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