› 5ek7

X-ray diffraction
1.9Å resolution

Structure of the autoinhibited Epha2 JMS-KD

Released:
DOI: 10.2210/pdb5ek7/pdb
PDB entry 5ek7 coloured by chain, front view.
PDB entry 5ek7 coloured by chain, side view.
PDB entry 5ek7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wei Q, Zheng J

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 35.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29317 (Residues: 583-876; Coverage: 31%)
Gene names: ECK, EPHA2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 63.475Å b: 75.242Å c: 80.483Å
α: 90° β: 112.67° γ: 90°
R-values:
R R work R free
0.172 0.171 0.205
Expression system: Escherichia coli

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