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Crystal structural of the TSC1-TBC1D7 complex

Source organism: Homo sapiens
Biochemical function: small GTPase binding
Biological process: negative regulation of TORC1 signaling
Cellular component: ciliary basal body

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00566
Domain description: Rab-GTPase-TBC domain
Occurring in:
  1. TBC1 domain family member 7
The deposited structure of PDB entry 5ejc contains 2 copies of Pfam domain PF00566 (Rab-GTPase-TBC domain) in TBC1 domain family member 7. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000195
Domain description: Rab-GAP-TBC domain
Occurring in:
  1. TBC1 domain family member 7
IPR035969
Domain description: Rab-GAP-TBC domain superfamily
Occurring in:
  1. TBC1 domain family member 7
IPR043039
Domain description: TBC1 domain family member 7, domain 2
Occurring in:
  1. TBC1 domain family member 7
IPR039842
Domain description: TBC1 domain family member 7
Occurring in:
  1. TBC1 domain family member 7

Structure domains

CATH CATH domains
1.10.472.80
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cyclin A; domain 1
Homology: Ypt/Rab-GAP domain of gyp1p, domain 3
Occurring in:
  1. TBC1 domain family member 7
The deposited structure of PDB entry 5ejc contains 2 copies of CATH domain 1.10.472.80 (Cyclin A; domain 1) in TBC1 domain family member 7. Showing 1 copy in chain A.
1.10.8.680
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: Ypt/Rab-GAP domain of gyp1p, domain 2
Occurring in:
  1. TBC1 domain family member 7
The deposited structure of PDB entry 5ejc contains 2 copies of CATH domain 1.10.8.680 (Helicase, Ruva Protein; domain 3) in TBC1 domain family member 7. Showing 1 copy in chain A.
1.10.10.750
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Ypt/Rab-GAP domain of gyp1p, domain 1
Occurring in:
  1. TBC1 domain family member 7
The deposited structure of PDB entry 5ejc contains 2 copies of CATH domain 1.10.10.750 (Arc Repressor Mutant, subunit A) in TBC1 domain family member 7. Showing 1 copy in chain A.

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