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Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I )

Source organism: Homo sapiens
Biochemical function: thrombospondin receptor activity
Biological process: positive regulation of reactive oxygen species metabolic process
Cellular component: blood microparticle

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EC 3.4.21.5: Thrombin

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Systematic name:
-
Alternative Name(s):
  • Activated blood-coagulation factor II
  • Beta-thrombin
  • Blood-coagulation factor IIa
  • E thrombin
  • Factor IIa
  • Fibrinogenase
  • Gamma-thrombin
  • Thrombase
  • Thrombin-C
  • Thrombofort
  • Topical
  • Tropostasin

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00051
Domain description: Kringle domain
Occurring in:
  1. Prothrombin
The deposited structure of PDB entry 5edm contains 2 copies of Pfam domain PF00051 (Kringle domain) in Prothrombin. Showing 2 copies in chain A.

PF00089
Domain description: Trypsin
Occurring in:
  1. Prothrombin
The deposited structure of PDB entry 5edm contains 1 copy of Pfam domain PF00089 (Trypsin) in Prothrombin. Showing 1 copy in chain A.

PF09396
Domain description: Thrombin light chain
Occurring in:
  1. Prothrombin
The deposited structure of PDB entry 5edm contains 1 copy of Pfam domain PF09396 (Thrombin light chain) in Prothrombin. Showing 1 copy in chain A.

PF00594
Domain description: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Occurring in:
  1. Prothrombin
The deposited structure of PDB entry 5edm contains 1 copy of Pfam domain PF00594 (Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain) in Prothrombin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000001
Domain description: Kringle
Occurring in:
  1. Prothrombin
IPR000294
Domain description: Gamma-carboxyglutamic acid-rich (GLA) domain
Occurring in:
  1. Prothrombin
IPR003966
Domain description: Prothrombin/thrombin
Occurring in:
  1. Prothrombin
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Prothrombin
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Prothrombin
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Prothrombin
IPR018056
Domain description: Kringle, conserved site
Occurring in:
  1. Prothrombin
IPR013806
Domain description: Kringle-like fold
Occurring in:
  1. Prothrombin
IPR038178
Domain description: Kringle superfamily
Occurring in:
  1. Prothrombin
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Prothrombin
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Prothrombin
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Prothrombin
IPR018992
Domain description: Thrombin light chain
Occurring in:
  1. Prothrombin
IPR037111
Domain description: Thrombin light chain domain superfamily
Occurring in:
  1. Prothrombin
IPR035972
Domain description: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Occurring in:
  1. Prothrombin

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