PDBe 5ea2

X-ray diffraction
2.01Å resolution

Crystal Structure of Holo NAD(P)H dehydrogenase, quinone 1

Released:

Function and Biology Details

Reaction catalysed:
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(P)H dehydrogenase [quinone] 1 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 276 amino acids
Theoretical weight: 31.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW P15559 (Residues: 1-273; Coverage: 100%)
Gene names: DIA4, NMOR1, NQO1
Sequence domains: Flavodoxin-like fold
Structure domains: Rossmann fold

Ligands and Environments


Cofactor: Ligand FAD 4 x FAD
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 56.93Å b: 107.16Å c: 99.76Å
α: 90° β: 100.68° γ: 90°
R-values:
R R work R free
0.182 0.18 0.216
Expression system: Escherichia coli BL21(DE3)