PDBe 5e5r

X-ray diffraction
2.6Å resolution

Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN3

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Receptor-type tyrosine-protein phosphatase gamma Chains: A, C
Molecule details ›
Chains: A, C
Length: 265 amino acids
Theoretical weight: 30.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23470 (Residues: 56-320; Coverage: 19%)
Gene names: PTPG, PTPRG
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase
Contactin-3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 193 amino acids
Theoretical weight: 21.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07409 (Residues: 124-316; Coverage: 19%)
Gene names: Cntn3, Pang, Pcs
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 74.138Å b: 90.526Å c: 147.448Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.187 0.249
Expression system: Escherichia coli