PDBe 5e4g

X-ray diffraction
1.5Å resolution

Crystal structure of human growth differentiation factor 11 (GDF-11)

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human GDF11.
Acta Crystallogr F Struct Biol Commun 72 160-4 (2016)
PMID: 26919518

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth/differentiation factor 11 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95390 (Residues: 299-407; Coverage: 29%)
Gene names: BMP11, GDF11
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41212
Unit cell:
a: 32.27Å b: 32.27Å c: 210.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.207
Expression system: Escherichia coli