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X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430)

X-ray diffraction
2.5Å resolution
PDB entry 5dmg coloured by chain, front view.
PDB entry 5dmg coloured by chain, side view.
PDB entry 5dmg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Microtubule-associated protein tau and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 19236.84 Å2
Buried surface area: 4568.44 Å2
Dissociation area: 798.47 Å2
Dissociation energy (ΔGdiss): 7.24 kcal/mol
Dissociation entropy (TΔSdiss): 7.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210467
Assembly 2
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Assembly Name: Microtubule-associated protein tau and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 18976.84 Å2
Buried surface area: 4427.48 Å2
Dissociation area: 708.22 Å2
Dissociation energy (ΔGdiss): 5.85 kcal/mol
Dissociation entropy (TΔSdiss): 7.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210467
Assembly 3
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Assembly Name: Microtubule-associated protein tau and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 19048.57 Å2
Buried surface area: 4082.1 Å2
Dissociation area: 547.53 Å2
Dissociation energy (ΔGdiss): 3.46 kcal/mol
Dissociation entropy (TΔSdiss): 6.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210467

Macromolecules

RB86 antibody Fab fragment heavy chain
Chains: C, E, H
Length: 211 amino acids
Theoretical weight: 21.98 KDa
Source organism: Oryctolagus cuniculus
Expression system: Cricetulus griseus
InterPro:
CATH: Immunoglobulins
RB86 antibody Fab fragment heavy chain in PDB entry 5dmg, assembly 1, front view.
RB86 antibody Fab fragment heavy chain in PDB entry 5dmg, assembly 1, side view.
RB86 antibody Fab fragment heavy chain in PDB entry 5dmg, assembly 1, top view.
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RB86 antibody Fab fragment light chain
Chains: D, F, L
Length: 219 amino acids
Theoretical weight: 23.54 KDa
Source organism: Oryctolagus cuniculus
Expression system: Cricetulus griseus
InterPro:
CATH: Immunoglobulins
RB86 antibody Fab fragment light chain in PDB entry 5dmg, assembly 1, front view.
RB86 antibody Fab fragment light chain in PDB entry 5dmg, assembly 1, side view.
RB86 antibody Fab fragment light chain in PDB entry 5dmg, assembly 1, top view.
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Microtubule-associated protein tau
Chains: P, X, Z
Length: 15 amino acids
Theoretical weight: 1.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 733-747; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Microtubule-associated protein tau in PDB entry 5dmg, assembly 1, front view.
Microtubule-associated protein tau in PDB entry 5dmg, assembly 1, side view.
Microtubule-associated protein tau in PDB entry 5dmg, assembly 1, top view.
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