› 5d18

X-ray diffraction
2.04Å resolution

Crystal structure of Mycobacterium tuberculosis Rv0302, form I

Released:
DOI: 10.2210/pdb5d18/pdb
PDB entry 5d18 coloured by chain, front view.
PDB entry 5d18 coloured by chain, side view.
PDB entry 5d18 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.
Chou TH, Delmar JA, Wright CC, Kumar N, Radhakrishnan A, Doh JK, Licon MH, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW
Protein Sci 24 1942-55 (2015)
PMID: 26362239

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O07229 (Residues: 1-210; Coverage: 100%)
Gene name: Rv0302
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

3 bound ligands:
Ligand IPA 1 x IPA
Ligand EPE 1 x EPE
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6122
Unit cell:
a: 116.628Å b: 116.628Å c: 94.178Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.192 0.215
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system.
Batt et al. (2020)
3 more

1 mention without citation

Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.
Chou et al. (2015)