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EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE

X-ray diffraction
2.8Å resolution
PDB entry 5czh coloured by chain, front view.
PDB entry 5czh coloured by chain, side view.
PDB entry 5czh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Epidermal growth factor receptor and peptide
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Multimeric state: hetero dimer
Accessible surface area: 15672.0 Å2
Buried surface area: 910.83 Å2
Dissociation area: 455.41 Å2
Dissociation energy (ΔGdiss): 4.57 kcal/mol
Dissociation entropy (TΔSdiss): 7.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132680

Macromolecules

Epidermal growth factor receptor
Chain: A
Length: 331 amino acids
Theoretical weight: 37.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 694-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Epidermal growth factor receptor in PDB entry 5czh, assembly 1, front view.
Epidermal growth factor receptor in PDB entry 5czh, assembly 1, side view.
Epidermal growth factor receptor in PDB entry 5czh, assembly 1, top view.
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Peptide substrate
Chain: B
Length: 9 amino acids
Theoretical weight: 1.25 KDa
Source organism: Escherichia coli H489
Expression system: Not provided
Peptide substrate in PDB entry 5czh, assembly 1, front view.
Peptide substrate in PDB entry 5czh, assembly 1, side view.
Peptide substrate in PDB entry 5czh, assembly 1, top view.
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