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WDR48 (2-580):USP46~ubiquitin ternary complex

Source organism: Homo sapiens
Biochemical function: deubiquitinase activity
Biological process: righting reflex
Cellular component: cytosol

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. WD repeat-containing protein 48
The deposited structure of PDB entry 5cvn contains 6 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in WD repeat-containing protein 48. Showing 6 copies in chain A.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 5cvn contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain C [auth D].

PF00443
Domain description: Ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 46
The deposited structure of PDB entry 5cvn contains 1 copy of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 46. Showing 1 copy in chain B.

PF11816
Domain description: Domain of unknown function (DUF3337)
Occurring in:
  1. WD repeat-containing protein 48

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. WD repeat-containing protein 48
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. WD repeat-containing protein 48
IPR018200
Domain description: Ubiquitin specific protease, conserved site
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 46
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. WD repeat-containing protein 48
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR028889
Domain description: Ubiquitin specific protease domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 46
IPR001394
Domain description: Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 46
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 46
IPR021772
Domain description: WDR48/Bun107
Occurring in:
  1. WD repeat-containing protein 48
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. WD repeat-containing protein 48
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. WD repeat-containing protein 48

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 46
The deposited structure of PDB entry 5cvn contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Ubiquitin carboxyl-terminal hydrolase 46. Showing 1 copy in chain B.

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