› › Structure analysis

CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11

X-ray diffraction
1.8Å resolution
PDB entry 5csz coloured by chain, front view.
PDB entry 5csz coloured by chain, side view.
PDB entry 5csz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Soluble APP-beta and IG-heavy chain and IG-light kappa chain
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 18879.79 Å2
Buried surface area: 5925.16 Å2
Dissociation area: 2,005.86 Å2
Dissociation energy (ΔGdiss): 22.13 kcal/mol
Dissociation entropy (TΔSdiss): 13.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209166
Assembly 2
Download    3D Visualisation
Assembly Name: Soluble APP-beta and IG-heavy chain and IG-light kappa chain
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 19095.66 Å2
Buried surface area: 5762.28 Å2
Dissociation area: 1,978.63 Å2
Dissociation energy (ΔGdiss): 21.93 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209166

Macromolecules

GANTENERUMAB FAB FRAGMENT HEAVY CHAIN
Chains: A, H
Length: 228 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
InterPro:
CATH: Immunoglobulins
GANTENERUMAB FAB FRAGMENT HEAVY CHAIN in PDB entry 5csz, assembly 1, front view.
GANTENERUMAB FAB FRAGMENT HEAVY CHAIN in PDB entry 5csz, assembly 1, side view.
GANTENERUMAB FAB FRAGMENT HEAVY CHAIN in PDB entry 5csz, assembly 1, top view.
Molecule details ›

Search similar proteins

GANTENERUMAB FAB FRAGMENT LIGHT CHAIN
Chains: B, L
Length: 215 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
InterPro:
CATH: Immunoglobulins
GANTENERUMAB FAB FRAGMENT LIGHT CHAIN in PDB entry 5csz, assembly 1, front view.
GANTENERUMAB FAB FRAGMENT LIGHT CHAIN in PDB entry 5csz, assembly 1, side view.
GANTENERUMAB FAB FRAGMENT LIGHT CHAIN in PDB entry 5csz, assembly 1, top view.
Molecule details ›

Search similar proteins

Amyloid-beta protein 40
Chains: D, E
Length: 11 amino acids
Theoretical weight: 1.33 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-682; Coverage: 2%)
Gene names: A4, AD1, APP
Amyloid-beta protein 40 in PDB entry 5csz, assembly 1, front view.
Amyloid-beta protein 40 in PDB entry 5csz, assembly 1, side view.
Amyloid-beta protein 40 in PDB entry 5csz, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links