› 5cqa

X-ray diffraction
2.13Å resolution

Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide (SGC - Diamond I04-1 fragment screening)

Released:
DOI: 10.2210/pdb5cqa/pdb
PDB entry 5cqa coloured by chain, front view.
PDB entry 5cqa coloured by chain, side view.
PDB entry 5cqa coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bradley A, Pearce N, Krojer T, Ng J, Talon R, Vollmar M, Jose B, von Delft F, Bountra C, Arrowsmith CH, Edwards A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2B Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIF8 (Residues: 2054-2166; Coverage: 5%)
Gene names: BAZ2B, KIAA1476
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand 2LY 1 x 2LY
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 83.16Å b: 96.94Å c: 58.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.175 0.222
Expression system: Escherichia coli

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