Structure analysis

UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

X-ray diffraction
3Å resolution
Source organism: Mus musculus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 41900 Å2
Buried surface area: 9000 Å2
Dissociation area: 2,400 Å2
Dissociation energy (ΔGdiss): 22 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -29 kcal/mol
Symmetry number: 2
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 41900 Å2
Buried surface area: 9000 Å2
Dissociation area: 2,400 Å2
Dissociation energy (ΔGdiss): 21 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -29 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B, C, D
Length: 587 amino acids
Theoretical weight: 67.32 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05769 (Residues: 18-604; Coverage: 100%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Pfam:
InterPro:
CATH:
SCOP:

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