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CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO [7.3.0.02,6]DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE

X-ray diffraction
2.5Å resolution
PDB entry 5cf6 coloured by chain, front view.
PDB entry 5cf6 coloured by chain, side view.
PDB entry 5cf6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase JAK2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-130063
Assembly 2
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Assembly Name: Tyrosine-protein kinase JAK2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-130063

Macromolecules

Tyrosine-protein kinase JAK2
Chains: A, B
Length: 321 amino acids
Theoretical weight: 37.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60674 (Residues: 839-1132; Coverage: 26%)
Gene name: JAK2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase JAK2 in PDB entry 5cf6, assembly 1, front view.
Tyrosine-protein kinase JAK2 in PDB entry 5cf6, assembly 1, side view.
Tyrosine-protein kinase JAK2 in PDB entry 5cf6, assembly 1, top view.
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