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Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4.

Paracuellos P, Briggs DC, Carafoli F, Lončar T, Hohenester E
Structure 23 2133-42 (2015)
Cited: 13 times
EuropePMC logo PMID: 26481812

Abstract

The C-type mannose receptor and its homolog Endo180 (or uPARAP, for urokinase plasminogen activator receptor-associated protein) mediate the endocytic uptake of collagen by macrophages and fibroblasts. This process is required for normal tissue remodeling, but also facilitates the growth and dissemination of tumors. We have determined the crystal structure at 2.5 Å resolution of the N-terminal region of Endo180, consisting of a ricin-like domain, a fibronectin type II (FN2) domain, and two C-type lectin (CTL) domains. The L-shaped arrangement of these domains creates a shallow trench spanning the FN2 and CTL1 domains, which was shown by mutagenesis to bind triple-helical and denatured collagen. Small-angle X-ray scattering showed that the L-shaped structure is maintained in solution at neutral and acidic pH, irrespective of calcium ion loading. Collagen binding was equally unaffected by acidic pH, suggesting that collagen release in endosomes is not regulated by changes within the Endo180 N-terminal region.

Articles - 5ao6 mentioned but not cited (2)

  1. Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein. Sandoval DR, Gomez Toledo A, Painter CD, Tota EM, Sheikh MO, West AMV, Frank MM, Wells L, Xu D, Bicknell R, Corbett KD, Esko JD. J Biol Chem 295 2804-2821 (2020)
  2. Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells. Wang Q, Liu Y, Wang H, Jiang P, Qian W, You M, Han Y, Zeng X, Li J, Lu H, Jiang L, Zhu M, Li S, Huang K, Tang M, Wang X, Yan L, Xiong Z, Shi X, Bai G, Liu H, Li Y, Zhao Y, Chen C, Qian P. Nat Commun 13 5657 (2022)


Reviews citing this publication (1)

  1. uPARAP/Endo180: a multifaceted protein of mesenchymal cells. Gucciardo F, Pirson S, Baudin L, Lebeau A, Noël A. Cell Mol Life Sci 79 255 (2022)

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  1. Structural basis of laminin binding to the LARGE glycans on dystroglycan. Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP. Nat Chem Biol 12 810-814 (2016)
  2. Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. Feinberg H, Jégouzo SAF, Lasanajak Y, Smith DF, Drickamer K, Weis WI, Taylor ME. J Biol Chem 296 100368 (2021)
  3. Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis. Jungwirth U, van Weverwijk A, Evans RJ, Jenkins L, Vicente D, Alexander J, Gao Q, Haider S, Iravani M, Isacke CM. Nat Commun 12 3516 (2021)
  4. Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery. Chun YY, Yap ZL, Seet LF, Chan HH, Toh LZ, Chu SWL, Lee YS, Wong TT, Tan TTY. Sci Rep 11 1470 (2021)
  5. A Novel CD206 Targeting Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice. Ghebremedhin A, Salam AB, Adu-Addai B, Noonan S, Stratton R, Ahmed MSU, Khantwal C, Martin GR, Lin H, Andrews C, Karanam B, Rudloff U, Lopez H, Jaynes J, Yates C. Cells 12 1254 (2023)
  6. The cryo-EM structure of the endocytic receptor DEC-205. Gully BS, Venugopal H, Fulcher AJ, Fu Z, Li J, Deuss FA, Llerena C, Heath WR, Lahoud MH, Caminschi I, Rossjohn J, Berry R. J Biol Chem 296 100127 (2021)
  7. Decreased levels of endocytic collagen receptor Endo180 in dermal fibroblasts lead to decreased production of type I collagen and increased expression of matrix metalloproteinase-1. Iwahashi H, Kawashima Y, Masaki H. Photodermatol Photoimmunol Photomed 38 150-157 (2022)
  8. Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity. Niu M, McGrath M, Sammon D, Gardner S, Morgan RM, Di Maio A, Liu Y, Bubeck D, Hohenester E. Wellcome Open Res 8 76 (2023)
  9. The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain. Nørregaard KS, Krigslund O, Behrendt N, Engelholm LH, Jürgensen HJ. J Biol Chem 295 9157-9170 (2020)
  10. Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch. Fresquet M, Lockhart-Cairns MP, Rhoden SJ, Jowitt TA, Briggs DC, Baldock C, Brenchley PE, Lennon R. Proc Natl Acad Sci U S A 119 e2202209119 (2022)


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