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Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF11976
Domain description: Ubiquitin-2 like Rad60 SUMO-like
Occurring in:
  1. Small ubiquitin-related modifier 1
The deposited structure of PDB entry 5aek contains 12 copies of Pfam domain PF11976 (Ubiquitin-2 like Rad60 SUMO-like) in Small ubiquitin-related modifier 1. Showing 1 copy in chain B.

PF02902
Domain description: Ulp1 protease family, C-terminal catalytic domain
Occurring in:
  1. Sentrin-specific protease 2
The deposited structure of PDB entry 5aek contains 12 copies of Pfam domain PF02902 (Ulp1 protease family, C-terminal catalytic domain) in Sentrin-specific protease 2. Showing 1 copy in chain S.

InterPro InterPro annotations
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR003653
Domain description: Ulp1 protease family, C-terminal catalytic domain
Occurring in:
  1. Sentrin-specific protease 2
IPR022617
Domain description: Rad60/SUMO-like domain
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR046332
Domain description: Small ubiquitin-related modifier 1, Ubl domain
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Small ubiquitin-related modifier 1
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Sentrin-specific protease 2

Structure domains

CATH CATH domains
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Small ubiquitin-related modifier 1
The deposited structure of PDB entry 5aek contains 12 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Small ubiquitin-related modifier 1. Showing 1 copy in chain B.
3.40.395.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Adenoviral Proteinase; Chain
Homology: Adenoviral Proteinase; Chain A
Occurring in:
  1. Sentrin-specific protease 2
The deposited structure of PDB entry 5aek contains 12 copies of CATH domain 3.40.395.10 (Adenoviral Proteinase; Chain) in Sentrin-specific protease 2. Showing 1 copy in chain C.

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