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Electron cryo-microscopy of an Abeta(1-42)amyloid fibril

Electron Microscopy
5Å resolution
PDB entry 5aef coloured by chain, front view.
PDB entry 5aef coloured by chain, side view.
PDB entry 5aef coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Amyloid-beta protein 42 complex
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Multimeric state: homo dimer
Accessible surface area: 7069.96 Å2
Buried surface area: 241.58 Å2
Dissociation area: 120.79 Å2
Dissociation energy (ΔGdiss): -6.72 kcal/mol
Dissociation entropy (TΔSdiss): 9.36 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138395
Complex Portal ID: CPX-1070

Macromolecules

P3(42)
Chains: A, B
Length: 28 amino acids
Theoretical weight: 2.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 686-713; Coverage: 4%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
InterPro:
P3(42) in PDB entry 5aef, assembly 1, front view.
P3(42) in PDB entry 5aef, assembly 1, side view.
P3(42) in PDB entry 5aef, assembly 1, top view.
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