PDBe 5xtz

X-ray diffraction
2.1Å resolution

Crystal structure of GAS41 YEATS bound to H3K27ac peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
YEATS domain-containing protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 163 amino acids
Theoretical weight: 18.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: O95619 (Residues: 15-159; Coverage: 64%)
Gene names: GAS41, YEATS4
Sequence domains: YEATS family
Histone H3.1 Chain: E
Molecule details ›
Chain: E
Length: 10 amino acids
Theoretical weight: 1.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 23-32; Coverage: 7%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 75.864Å b: 80.663Å c: 107.028Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.233
Expression systems:
  • Escherichia coli K-12
  • Not provided