› 5xgm

X-ray diffraction
2.95Å resolution

Crystal structure of EGFR 696-1022 T790M in complex with Go6976

Released:
DOI: 10.2210/pdb5xgm/pdb
PDB entry 5xgm coloured by chain, front view.
PDB entry 5xgm coloured by chain, side view.
PDB entry 5xgm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural pharmacological studies on EGFR T790M/C797S.
Kong LL, Ma R, Yao MY, Yan XE, Zhu SJ, Zhao P, Yun CH
Biochem Biophys Res Commun 488 266-272 (2017)
PMID: 28456628

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 85X 1 x 85X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: I23
Unit cell:
a: 146.31Å b: 146.31Å c: 146.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.232
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Structure-Activity Relationship Studies Based on Quinazoline Derivatives as EGFR Kinase Inhibitors (2017-Present).
Șandor et al. (2023)
2 more

1 mention without citation

17β-Estradiol promotes angiogenesis of bone marrow mesenchymal stem cells by upregulating the PI3K-Akt signaling pathway.
Zhang et al. (2022)