PDBe 5xgi

X-ray diffraction
2.56Å resolution

Crystal structure of PI3K complex with an inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Song K, Yang X, Zhao Y, Jian Z

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 1052 amino acids
Theoretical weight: 122.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P42336 (Residues: 8-1059; Coverage: 99%)
Gene name: PIK3CA
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 277 amino acids
Theoretical weight: 33.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P27986 (Residues: 322-598; Coverage: 38%)
Gene names: GRB1, PIK3R1
Sequence domains: SH2 domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 71.348Å b: 135.825Å c: 150.245Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.239 0.29
Expression system: Spodoptera frugiperda