PDBe 5xgh

X-ray diffraction
2.97Å resolution

Crystal structure of PI3K complex with an inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Song K, Yang X, Zhao Y, Jian Z

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 1048 amino acids
Theoretical weight: 122.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P42336 (Residues: 8-1055; Coverage: 98%)
Gene name: PIK3CA
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 277 amino acids
Theoretical weight: 33.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P27986 (Residues: 322-598; Coverage: 38%)
Gene names: GRB1, PIK3R1
Sequence domains: SH2 domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 70.36Å b: 136.312Å c: 149.408Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.28
Expression system: Spodoptera frugiperda