PDBe 5x2l

X-ray diffraction
1.81Å resolution

Crystal Structure of Human Serine Racemase

Released:

Function and Biology Details

Reactions catalysed:
(1a) D-serine = 2-aminoprop-2-enoate + H(2)O
(1a) L-serine = 2-aminoprop-2-enoate + H(2)O
L-serine = D-serine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine racemase Chains: A, B
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 37.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZT4 (Residues: 1-340; Coverage: 100%)
Gene name: SRR
Sequence domains: Pyridoxal-phosphate dependent enzyme

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P21212
Unit cell:
a: 80.12Å b: 112.59Å c: 88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.258
Expression system: Escherichia coli