PDBe 5wwu

X-ray diffraction
2.79Å resolution

Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25

Released:
Entry authors: Zhao M, Liu K, Chai Y, Qi J, Liu J, Gao GF

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-24 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05534 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Matrix protein 1 Chain: E
Molecule details ›
Chain: E
Length: 11 amino acids
Theoretical weight: 1.44 KDa
Source organism: Influenza A virus (A/chicken/China/028/2014(H7N9))
Expression system: Not provided
UniProt:
  • Canonical: A0A0X9JHC1 (Residues: 99-109; Coverage: 4%)
Gene names: M, M1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 71.752Å b: 79.099Å c: 88.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.284
Expression systems:
  • Escherichia coli
  • Not provided