› 5wwu

X-ray diffraction
2.79Å resolution

Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25

Released:
DOI: 10.2210/pdb5wwu/pdb
PDB entry 5wwu coloured by chain, front view.
PDB entry 5wwu coloured by chain, side view.
PDB entry 5wwu coloured by chain, top view.
Source organisms:
Primary publication:
Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.
Zhao M, Liu K, Luo J, Tan S, Quan C, Zhang S, Chai Y, Qi J, Li Y, Bi Y, Xiao H, Wong G, Zhou J, Jiang T, Liu W, Yu H, Yan J, Liu Y, Shu Y, Wu G, Wu A, Gao GF, Liu WJ
mBio 9 (2018)
PMID: 30087171

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-102819 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Matrix protein 1 Chain: E
Molecule details ›
Chain: E
Length: 11 amino acids
Theoretical weight: 1.44 KDa
Source organism: Influenza A virus (A/chicken/China/028/2014(H7N9))
Expression system: Not provided
UniProt:
  • Canonical: A0A0X9JHC1 (Residues: 99-109; Coverage: 4%)
Gene names: M, M1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 71.752Å b: 79.099Å c: 88.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.284
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

Pandemic potential of highly pathogenic avian influenza clade 2.3.4.4 A(H5) viruses.
Yamaji et al. (2020)
4 more

1 mention without citation

Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.
Zhao et al. (2018)