PDBe 5wpa

X-ray diffraction
2.29Å resolution

Structure of human SFPQ/PSPC1 heterodimer

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Splicing factor, proline- and glutamine-rich Chain: A
Molecule details ›
Chain: A
Length: 261 amino acids
Theoretical weight: 29.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23246 (Residues: 276-535; Coverage: 37%)
Gene names: PSF, SFPQ
Sequence domains:
Paraspeckle component 1 Chain: B
Molecule details ›
Chain: B
Length: 261 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WXF1 (Residues: 61-320; Coverage: 50%)
Gene names: PSP1, PSPC1
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 89.229Å b: 67.841Å c: 92.204Å
α: 90° β: 95.06° γ: 90°
R-values:
R R work R free
0.221 0.219 0.272
Expression system: Escherichia coli BL21(DE3)