PDBe 5wb8

X-ray diffraction
3Å resolution

Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chains: A, D
Molecule details ›
Chains: A, D
Length: 507 amino acids
Theoretical weight: 56.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P00533 (Residues: 25-525; Coverage: 42%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Epigen Chains: B, C
Molecule details ›
Chains: B, C
Length: 61 amino acids
Theoretical weight: 6.87 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
  • Canonical: Q6UW88 (Residues: 49-108; Coverage: 46%)
Gene names: EPGN, UNQ3072/PRO9904

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P4322
Unit cell:
a: 104.05Å b: 104.05Å c: 285.94Å
α: 90° β: 90° γ: 90°
R R work R free
0.268 0.265 0.312
Expression systems:
  • Spodoptera frugiperda
  • Drosophila melanogaster