PDBe 5w7j

X-ray diffraction
2.2Å resolution

X-ray structure of the E89A variant of ankyrin repeat domain of DHHC17 in complex with Snap25b peptide

Released:

Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Palmitoyltransferase ZDHHC17 Chains: A, C
Molecule details ›
Chains: A, C
Length: 239 amino acids
Theoretical weight: 26.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IUH5 (Residues: 50-284; Coverage: 37%)
Gene names: HIP14, HIP3, HSPC294, HYPH, KIAA0946, ZDHHC17
Sequence domains: Ankyrin repeats (3 copies)
Synaptosomal-associated protein 25 Chains: B, D
Molecule details ›
Chains: B, D
Length: 10 amino acids
Theoretical weight: 984 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60880 (Residues: 111-120; Coverage: 5%)
Gene names: SNAP, SNAP25

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P64
Unit cell:
a: 87.736Å b: 87.736Å c: 128.007Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.17 0.211
Expression systems:
  • Escherichia coli
  • Not provided