PDBe 5w69

X-ray diffraction
2.8Å resolution

HLA-C*06:02 presenting ARFNDLRFV

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, Cw-6 alpha chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 276 amino acids
Theoretical weight: 32.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q29963 (Residues: 25-300; Coverage: 81%)
Gene names: HLA-C, HLAC
Sequence domains:
Beta-2-microglobulin Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Runt-related transcription factor 3 Chains: I, J, K, L
Molecule details ›
Chains: I, J, K, L
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q13761 (Residues: 133-141; Coverage: 2%)
Gene names: AML2, CBFA3, PEBP2A3, RUNX3

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 51.182Å b: 182.137Å c: 222.736Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.164 0.223
Expression systems:
  • Escherichia coli BL21
  • Not provided