PDBe 5vlr

X-ray diffraction
2.8Å resolution

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A
Molecule details ›
Chain: A
Length: 1013 amino acids
Theoretical weight: 115.96 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: NEW O00329 (Residues: 17-1029; Coverage: 97%)
Gene name: PIK3CD
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 170 amino acids
Theoretical weight: 20.99 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: NEW P27986 (Residues: 431-600; Coverage: 24%)
Gene names: GRB1, PIK3R1
Sequence domains: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 90.847Å b: 108.579Å c: 142.734Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.279
Expression system: unidentified baculovirus