PDBe 5v7z

Solid-state NMR

SSNMR Structure of the Human RIP1/RIP3 Necrosome

Released:
Source organism: Homo sapiens
Entry authors: Mompean M, Li W, Li J, Laage S, Siemer AB, Wu H, McDermott AE

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Receptor-interacting serine/threonine-protein kinase 3 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 15 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y572 (Residues: 448-462; Coverage: 3%)
Gene names: RIP3, RIPK3
Receptor-interacting serine/threonine-protein kinase 1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 18 amino acids
Theoretical weight: 2.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13546 (Residues: 532-549; Coverage: 3%)
Gene names: RIP, RIP1, RIPK1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 10%
Refinement method: molecular dynamics
Chemical shifts: BMR30273  
Expression system: Escherichia coli