PDBe 5v4n

X-ray diffraction
3.4Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 189 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: NEW P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
HLA class II histocompatibility antigen, DRB1-1 beta chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 216 amino acids
Theoretical weight: 24.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: NEW P04229 (Residues: 8-11, 30-219; Coverage: 73%)
Gene name: HLA-DRB1
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 82.086Å b: 118.41Å c: 120.875Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.263
Expression system: Trichoplusia ni