PDBe 5uzu

X-ray diffraction
2.4Å resolution

Immune evasion by a Staphylococcal Peroxidase Inhibitor that blocks myeloperoxidase

Released:

Function and Biology Details

Reaction catalysed:
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Uncharacterised protein Chain: B
Molecule details ›
Chain: B
Length: 71 amino acids
Theoretical weight: 7.98 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2G0X2 (Residues: 30-97; Coverage: 93%)
Gene name: SAOUHSC_00401
Myeloperoxidase Chain: A
Molecule details ›
Chain: A
Length: 578 amino acids
Theoretical weight: 65.91 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P05164 (Residues: 167-744; Coverage: 83%)
Gene name: MPO
Sequence domains: Animal haem peroxidase

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 129.034Å b: 92.944Å c: 80.394Å
α: 90° β: 120.14° γ: 90°
R-values:
R R work R free
0.187 0.184 0.241
Expression systems:
  • Escherichia coli
  • Mus musculus