PDBe 5uwl

X-ray diffraction
2.55Å resolution

Matrix metalloproteinase-13 complexed with selective inhibitor compound (S)-17a

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 172 amino acids
Theoretical weight: 19.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45452 (Residues: 104-274; Coverage: 38%)
Gene name: MMP13
Sequence domains: Matrixin

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P6422
Unit cell:
a: 129.962Å b: 129.962Å c: 142.076Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.24
Expression system: Escherichia coli BL21(DE3)