PDBe 5uoy

X-ray diffraction
1.82Å resolution

Crystal structure of human PDE1B catalytic domain in complex with inhibitor 16j (6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01064 (Residues: 146-506; Coverage: 67%)
Gene names: PDE1B, PDE1B1, PDES1B
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P43212
Unit cell:
a: 87.507Å b: 87.507Å c: 134.714Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.221
Expression system: Escherichia coli